Downregulation of GSTK1 Is a Common Mechanism Underlying Hypertrophic Cardiomyopathy
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چکیده
منابع مشابه
Downregulation of GSTK1 Is a Common Mechanism Underlying Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy and is associated with a number of potential outcomes, including impaired diastolic function, heart failure, and sudden cardiac death. Various etiologies have been described for HCM, including pressure overload and mutations in sarcomeric and non-sarcomeric genes. However, the molecular pathogenesis of HCM remain...
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A 40 year old male, a known case of hypertrophic cardiomyopathy, was admitted for catheterization. At catheterization and angiography, septum was hypertrophied to about 5cm and diffuse coronary artery aneurysm was revealed. We found no previous report of coronary artery aneurysm in hypertrophic cardiomyopathy.
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Sir, Shapiro and Zezulka in their recent paper (1983; 50: 530-3) draw conclusions regarding the prognosis of hypertrophic cardiomyopathy, which if substantiated would greatly alter the attitude to the disease of physician and patient alike. We would suggest, however, that the data presented provide a less substantive basis for the authors' conclusions than would at first appear. No information ...
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BACKGROUND Drugs with negative inotropic effect are widely used to decrease obstruction in hypertrophic cardiomyopathy (HCM). However, the mechanism of therapeutic benefit has not been studied. METHODS AND RESULTS We used M-mode, two-dimensional, and pulsed Doppler echocardiography to study 11 patients with obstructive HCM before and after medical elimination of left ventricular outflow tract...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2016
ISSN: 1663-9812
DOI: 10.3389/fphar.2016.00162